The Science

Formulated by gastroenterologists.
Guided by evidence.

A closer look at the ingredient research, clinical reasoning, and quality standards behind Daily Gut Reset — a gut health supplement designed to support regularity, digestive comfort, and a less bloated feel.*

Board-Certified Gastroenterologists 6+ clinically studied ingredients

Our standard

Know what’s inside. Know why it matters.

Most gut supplements ask you to trust the front of the label. We built Daily Gut Reset differently: with clear ingredients, intentional doses, and a formula designed around the key pieces of daily gut support.

01
Clinical Perspective

Formulated by gastroenterologists with a practical understanding of everyday digestive health.

02
Evidence-Led Selection

Ingredients were chosen for their role in daily gut support, not because they were trending.

03
Dose Discipline

Every dose was selected with intention, based on the role each ingredient plays in the formula.

04
Whole-Formula Design

Built around complementary layers of gut support, so the formula works as a daily system rather than a collection of stand-alone ingredients.

What it supports

Four systems. One daily ritual.

Daily Gut Reset was designed around four connected layers: prebiotic fiber for regularity, probiotics for microbiome support, botanicals for digestive comfort, and gut-brain support for a more complete daily ritual.*

Fiber and regularity
01
/ Fiber & Regularity

Soluble fibers support stool consistency, digestive rhythm, and more predictable regularity.*

Microbiome balance
02
/ Microbiome Balance

Probiotic strains selected to support the gut microbiome and everyday digestive health.*

Motility and comfort
03
/ Motility & Comfort

Kiwifruit, ginger, and peppermint oil selected to support digestive comfort and a less bloated feel.*

Gut-brain axis
04
/ Gut-Brain Axis

L-theanine and green tea extract add a gut-brain support layer to the formula.*

The formula

Four building blocks.
Every one has a reason.

A closer look at the four parts of LIST/OF and why each one was included in the daily formula.

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What it is

PHGG and organic acacia fiber, two soluble prebiotic fibers selected for daily digestive support.

Why we included it

Prebiotic fiber helps support regularity, stool consistency, and a healthy gut environment. PHGG and acacia were chosen because they are gentle, well-tolerated fibers that fit easily into a daily routine.*

What it supports

Regularity, digestive rhythm, a less bloated feel, and nourishment for beneficial gut bacteria.*

What it is

Bifidobacterium lactis and Lactobacillus plantarum, two probiotic strains selected to support the gut microbiome.

Why we included it

Prebiotic fiber helps set the foundation, while probiotics add another layer of daily gut support. These strains were chosen to complement the fiber system and support a balanced gut microbiome.*

What it supports

Microbial balance, digestive comfort, regularity, and everyday gut function.*

What it is

A targeted digestive botanical blend with kiwifruit extract, ginger extract, and peppermint oil, selected to support everyday gut comfort.

Why we included it

Fiber and probiotics are important, but digestive comfort is part of the daily experience. These botanicals add a comfort layer to the formula, helping support a healthier digestive rhythm and a less bloated feel.*

What it supports

Everyday digestive comfort, digestive rhythm, post-meal ease, and a less bloated feel.*

What it is

A gut-brain support pairing with L-theanine and green tea extract, selected to round out a more complete daily gut health formula.

Why we included it

Gut health is connected to more than digestion alone. This pairing adds a gut-brain support layer alongside prebiotic fiber, probiotics, and digestive botanicals.*

What it supports

Gut-brain support, everyday digestive comfort, and a more complete daily gut ritual.*

Beyond digestion

Your gut has a nervous system.
We formulated for it.

The enteric nervous system, sometimes called the “second brain,” contains hundreds of millions of neurons and communicates with the brain through the gut-brain axis.

That connection changes how we think about daily gut support. Digestion does not happen in isolation; it is shaped by rhythm, routine, stress, and the signals moving between the gut and brain. LIST/OF was formulated with that bigger picture in mind.*

Gut-brain neural network visualization
500M
Estimated neurons in the enteric nervous system.
90%
A large share of the body’s serotonin is produced in the gut.
2-way
The gut and brain communicate in both directions through the gut-brain axis.

Daily gut support

Ready to make it simple?

Daily Gut Reset brings the key pieces of daily gut support into one stick pack.

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Quality standard

Manufactured in the USA to cGMP standards.

Daily Gut Reset is manufactured in a U.S. facility following current Good Manufacturing Practices for dietary supplements, with finished-product batch documentation for every run.

/ cGMP Manufacturing

Manufactured according to FDA current Good Manufacturing Practice requirements for dietary supplements.

/ Batch Documentation

Each finished-product batch is reviewed and supported by quality documentation before release.

/ Clear Label

No proprietary blends. Ingredients and doses are listed clearly, so you know what you’re taking.

/ Additional Testing

Nutritional and gluten testing support the Supplement Facts Panel and finished-product labeling.

Founder standard

Built with clinical perspective.

Daily Gut Reset is a gastroenterologist-founded gut health supplement built with the same discipline we wanted behind a daily formula: clear ingredients, intentional doses, and a reason for every layer.

As board-certified gastroenterologists, we created LIST/OF to bring more clarity to daily gut support — combining ingredient research, clinical reasoning, and the realities of a routine that is simple enough to keep.

Ami Patel, MD & Darin Dufault, MD Board-Certified Gastroenterologists · Co-Founders, LIST/OF
Read our story →

The evidence

The research behind the formula.

LIST/OF was built from ingredient-level research, clinical reasoning, and daily-use formulation standards. The references below helped inform our formulation approach.

These are ingredient-level references, not clinical trials of the finished LIST/OF formula. Study ingredients, strains, doses, forms, and populations may differ from the finished formula.

  1. 1 Abe A, Morishima S, Kapoor MP, et al. Partially hydrolyzed guar gum is associated with improvement in gut health, sleep, and motivation among healthy subjects. J Clin Biochem Nutr. 2023;72(2):189–197.
  2. 2 JanssenDuijghuijsen L, van den Belt M, Rijnaarts I, et al. Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial. Eur J Nutr. 2024;63(5):1983–1994.
  3. 3 Araújo MM, Vogado CO, Mendes MM, Gonçalves VSS, Botelho PB. Effects of Bifidobacterium animalis subspecies lactis supplementation on gastrointestinal symptoms: systematic review with meta-analysis. Nutr Rev. 2022;80(6):1619–1633.
  4. 4 Zhang C, Zhang Y, Ma K, et al. Lactobacillus plantarum Lp3a improves functional constipation: evidence from a human randomized clinical trial and animal model. Ann Transl Med. 2022;10(6):316.
  5. 5 Gearry R, Fukudo S, Barbara G, et al. Consumption of 2 Green Kiwifruits Daily Improves Constipation and Abdominal Comfort — Results of an International Multicenter Randomized Controlled Trial. Am J Gastroenterol. 2023;118(6):1058–1068.
  6. 6 Baek HI, Ha NR, Kim C, et al. Efficacy and safety of steamed ginger extract for gastric health: a randomized, double-blind, placebo-controlled multi-center clinical trial. Food Funct. 2025;16(18):7316–7329.
  7. 7 Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007;74(1):39–45.

Start your ritual

The science is clear.
The rest is up to you.

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